Record 8-8
| EVENT | DATE | VENUE/CITY | |
| Arizona Cardinals vs. San Francisco 49ers |
9/13/2009 | University of Phoenix Stadium Glendale, AZ |
20-16 W |
| San Francisco 49ers vs. Seattle Seahawks |
9/20/2009 | Candlestick Park San Francisco, CA |
23-10 W |
| Minnesota Vikings vs. San Francisco 49ers |
9/27/2009 | Metrodome Minneapolis, MN |
24-27 L |
| San Francisco 49ers vs. St Louis Rams |
10/4/2009 | Candlestick Park San Francisco, CA |
35-0 W |
| San Francisco 49ers vs. Atlanta Falcons |
10/11/2009 | Candlestick Park San Francisco, CA |
10-45 L |
| Houston Texans vs. San Francisco 49ers |
10/25/2009 | Reliant Stadium Houston, TX |
21-24 L |
| Indianapolis Colts vs. San Francisco 49ers |
11/1/2009 | Lucus Oil Field Indianapolis, IN |
14-18 L |
| San Francisco 49ers vs. Tennessee Titans |
11/8/2009 | Candlestick Park San Francisco, CA |
27-34 L |
| San Francisco 49ers vs. Chicago Bears |
11/12/2006 | Candlestick Park San Francisco, CA |
10-6 W |
| Green Bay Packers vs. San Francisco 49ers |
11/22/2009 | Lambeau Field Green Bay, WI |
24-30 L |
| San Francisco 49ers vs. Jacksonville Jaguars |
11/29/2009 | Candlestick Park San Francisco, CA |
20-3 W |
| Seattle Seahawks vs. San Francisco 49ers |
12/6/2009 | Qwest Field Seattle, WA |
17-20 L |
| San Francisco 49ers vs. Arizona Cardinals |
12/14/2009 | Candlestick Park San Francisco, CA |
24-9 W |
| Philadelphia Eagles vs. San Francisco 49ers |
12/20/2009 | Lincoln Financial Field Philadelphia, PA |
13-27 L |
| San Francisco 49ers vs. Detroit Lions |
12/27/2009 | Candlestick Park San Francisco, CA |
20-6 W |
| St Louis Rams vs. San Francisco 49ers |
1/3/2010 | Edward Jones Dome St Louis, MO |
28-6 W |
